Association between MDM2 SNP309 Polymorphism and Breast Cancer Risk in Chinese Women / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 131-133, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-403875
ABSTRACT
Objective:
To investigate the correlation of MDM2 SNP309 polymorphism with breast cancer risk in Chinese women.Methods:
The polymorphism of MDM2 SNP309 was detected by PCR-restriction frag-ment length polymorphisms assay (PCR-RFLP) in 698 women with primary breast cancer and 525 healthy controls.Results:
Compared with the T/T genotype, the G allele (T/G or G/G) was not associated with an in-creased risk of breast cancer in the entire population studied (T/G, adjusted OR=1.2, 95% CI 0.8-1.6, P=0.30; G/G, adjusted OR=1.0, 95% CI 0.7 ~ 1.5, P=0.88). Among postmenopausal women, the G allele (T/G or G/G) was significantly associated with an increased risk of breast cancer (T/G, adjusted OR=1.8, 95% CI1.2~3.0, P=0.011; G/G, adjusted OR=1.9, 95% CI 1.2~3.3, P=0.014). But this association was not ob-served among premenopausal women.Conclusion:
MDM2 SNP309 heterozygous T/G genotype and homozy-gous mutant GIG genotype increase breast cancer risk in postmenopausal Chinese women.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2010
Type:
Article
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