The preliminary research of relationship between Toll-like receptor and the immunoloregulation of Sertoli cell / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 155-159, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-403906
ABSTRACT
Objective:
To investigate the relationship between Toll-like receptor and the immune regulation about inflammation by Sertoli cell in vitro.Methods:
Here we examined the expression and potential functions of TLR family in rat Sertoli cells.Using our well-characterized urealyticum(UU) induced model we tested the expression changes of TLR2 and TLR6 at 12~(th),24~(th),36~(th) hours after UU infection in vitro.Results:
We demonstrated that TLR2-8 are highly expressed;TLR9 and TLR10 are expressed at relatively low level;the expression of TLR1 and TLR5 are not detected in normal rat Sertoli cells.Comparing with control group,Sertoli cells express more TLR2 and TLR6 after infected by UU.Conclusion:
There is some relationship between the activation of TLRs and the immune regulation about inflammation by Sertoli cell.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2010
Type:
Article
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