The enhancement of Astragalus Polysaccharide on specific immunotherapy in asthmatic mouse / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 132-135, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-403915
ABSTRACT
Objective:
To explore the effects the of Astragalus Polysaccharide on specific immune therapy in a mouse model of asthma.Methods:
Ninety SPF(Specific pathogen Free) BALB/c mice were randomly divided into six groups.The experimental groups were sensitized with OVA,treated with SIT or APS or their joint application.Then the mice were excited with 1% OVA.24 hours after the last excition,the numbers of the total inflammation cells and esoinophils(EOS) in BALF were counted.The left lung tissues were used to perform histological analysis.IFN-γ and IL-4 in peripheral blood were analysed by ELISA.Results:
After the therapy,asthma-associated lung inflammation was inhibited,and the numbers of total cells and EOS decreased.IFN-γ level was raised and IL-4 level was lowered.Conclusion:
APS can enhance SIT.It may result from affecting production of both the IFN-γ and IL-4.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2010
Type:
Article
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