Effects of CTGF on the periodontal tissue remolding during orthodontic tooth movement / 实用口腔医学杂志

ABSTRACT

Objective: To study the effects of CTGF on the periodontal tissue remolding during orthodontic tooth movement. Methods: A mouse model of orthodontic tooth movement was established. The CTGF and NS were injected into the periodontal tissue of the first molar. HE staining, immunohistochemical staining and automatic image analysis system were used to detect the changes of periodontal tissue and the expression of VEGF. Results: The periodontal tissue remolding accompanied the over expression of VEGF during the orthodontic tooth movement. At day 7, the remolding was most active and the expression of VEGF was the highest. CTGF injection induced acceleration of periodontal remolding and up-regulating the expression of VEGF during orthodontic tooth movement, especially at day 7 and day 15 after the orthodontic force were applied. Conclusion: In the mouse model of orthodontic tooth movement, periodontal CTGF injection induces over expression of VEGF and accelerates the periodontal remodeling during orthodontic tooth movement.