Prediction of the secondary structure and B cell epitopes for the Izumo protein of Homo Sapiens / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 37-40, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-404149
ABSTRACT
Objective:
To predict and analyze the secondary structure and B cell epitopes of Izumo protein.Methods:
The secondary structure and flexible regions of Izumo protein were predicted by the methods of Chou-Fasman,Gamier-Robson and Karplus-Schulz.Moreover,hydrophilicity plot,surface probability plot and antigenic index of Izumo protein were predicted by the methods of Kyte-Doolitde,Emini and Jameson-Wolf,respectively.Results:
Izumo protein contained moreαhelix regions.There were several centers ofαhelix in the regions of 6-17,30-40,88-99,103-120,153-160,173-188,249-260,283-297,334-338 and 339-346 of Izumo protein,and several centers of βsheet in the regions of 21-25,198-200,245-248 and 320-323.Moreover,many distinct B cell epitopes in Izumo protein possibly localized in the regions of 3642,62-66,94-99,118-122,129-132,151-154,161-164,173-177,205-208,212-216,256-265,271-276,283-288,314-318 and 336-350.Conclusion:
These results are helpful for identification of the dominant B cell epitopes and the functional domains of Izumo protein.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2010
Type:
Article
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