Expression of SARS-CoV functional receptor angiotensin-converting enzyme 2 in nephritic epithelium of primates / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 158-162, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-404164
ABSTRACT
AIM:
To investigate the expression of angiotensin-converting enzyme 2 (ACE2) in nephritic epithelium of primates.METHODS:
The expression of ACE2 in Vero E6 cells was detected by the techniques of RT-PCR and immunocytochemistry (ICC) techniques. The distribution of ACE2 protein in kidney tissues of two Rhesus monkeys and two normal human cases was observed by immunohistochemistry (IHC) techniques.RESULTS:
Vero E6 cells were found to express both ACE2 mRNA and protein. ACE2 protein was mainly located in epithelium of proximal tubules of Rhesus monkey and human kidney.CONCLUSION:
The expression of ACE2 in epithelium of primate kidney may provide the condition for SARS-CoV entry,which may be one of the reasons for inducing renal damage in SARS patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2010
Type:
Article
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