The expression and clinical significance of mTOR/P70S6K signaling pathway in cervical cancer / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
; (6): 10-13, 2010.
Article
in Zh
| WPRIM
| ID: wpr-404407
Responsible library:
WPRO
ABSTRACT
Objective To evaluate the expression and function of mammalian target of rapamycin (mTOR) and its substrate kinase P70S6K in mTOR/P70S6K signal pathway in cervical carcinogenesis. Methods The expression of mTOR and P70S6K in normal cervix uteri or cervical cancer was detected by the immunohistochemistry and RT-PCR methods. Results Compared to those in normal cervix uteri, both mRNA and protein of mTOR/P70S6K in cervical carcinomas were significantly increased (P<0.05). There was a positive correlation between mTOR gene and P70S6K gene expression in cervical cancer (r=0.746, P<0.001). Conclusion High expression of mTOR and P7OS6K may play an important role in the pathogenesis and development of cervical cancer.
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WPRIM
Language:
Zh
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Year:
2010
Type:
Article