Theoretical research and application potential of amphiphilic polymers containing polyethylene glycol and their micelles used as drug carriers / 中国组织工程研究

ABSTRACT

OBJECTIVE: To review classification and synthesis of amphiphilic polymers containing polyethylene glycol and the application as drug carriers.DATA SOURCE A computer-based research was conducted in SCI-Expanded, El Compendex and China Journal Full-text Database for articles concerning classification and synthesis of amphiphilic polymers containing polyethylene glycol and their micelles application as drug carriers published from January 2000 to July 2009.DATA SELECTION A total of 616 articles were primarily obtained. Following reading titles and abstract, articles addressing detail classification and synthesis of amphiphilic polymers containing polyethylene glycol and representative micellar influencing factor were included. Totally 31 English and Chinese literatures were collected for further analysis.MAIN OUTCOME MEASURES: Classification, synthesis and drug vector mechanism of amphiphilic polymers containing polyethylene glycol and the micellar application as drug carriers were measured.RESULTS: Star-shaped copolymer could elevate micellar stability, but there were many arm numbers, whicti might induced a decrease in drug carrier volume. Special group introduced in copolymer contributed to the combination of drug and carrier. To connect target group could provide target transport property. The length and density of polyethylene glycol chain in copolymer was related to micellar function. Changed the length and density of polyethylene glycol could obtain polymer micelles that circulated in vivo for a long time.CONCLUSION: Amphiphilic polymers containing polyethylene glycol has outstanding potential in medical drug carrier field and isolation technique.