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The Association of FGFR2 rs1219648 Polymorphism with Susceptibility of Breast Cancer in Han Population in Guizhou Province / 中国肿瘤临床
Chinese Journal of Clinical Oncology ; (24): 29-31, 2010.
Article in Chinese | WPRIM | ID: wpr-404890
ABSTRACT

Objective:

To investigate the association between polymorphisms of FGFR2 and the susceptibility of breast cancer in Han population in Guizhou province.

Methods:

Genotyping was performed using PCR-sequence-specific primers(PCR-SSP)in 106 histologically confirmed breast cancer cases and 116 cancer-free controls.

Results:

The genotype frequencies of rs1219648 TT,TC,and CC were 50%,25.47%.and 24.53% in breast cancer cases and 29.31%,48.28%,and 22.41% in the controls.The gene frequencies of T in breast cancer cases and the controls were 62.74% and 53.45%.respectively.The gene frequencies of C were 37.26% and 46.55%.respectively.The distribution of allele and genotype frequencies of FGFR2 rs1219648 was statistically different between breast cancer cases and the controls(P<0.05).

Conclusion:

FGFR2 rs1219648 polymorphism influences the susceptibility of breast cancer.TT genotype might serve as a risk factor for breast cancer.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Chinese Journal of Clinical Oncology Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Chinese Journal of Clinical Oncology Year: 2010 Type: Article