The Influence of Recombinant Human α-2b Interferon Capsule for Vaginal Foams on the Negative Conversion Rate of HPV / 实用妇产科杂志
Journal of Practical Obstetrics and Gynecology
;
(12): 733-735, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-404980
ABSTRACT
Objective:
To explore the effect and mechanism of Xinfuning( recombinant human α-2b interferon capsule for vaginal foams) on the clearance of human papilloma virus (HPV).Methods:
The patients with HPV infection were divided into experimental group (Xinfuning group) and control group (Shurunshuan group, a common recombinant human interferon α-2b in suppository form) .The HPV negative conversion rate was compared between the two groups after action on vaginal posterior fomix. The content of cytokines IL-4, IL-10, IFN-γ, TNF-a in the cervical region before or after the application was detected by ELISA.Results:
The negative conversion rate in the experimental group was higher than that in the control group ( P<0.05). The content of IL-4, IL-10 was decreased and the cont ent of IFN-γ,TNF-α was increased apparently( P < 0.05).Conclusions:
Interferon has the effect on clearance of HPV infection by regulating Th1/Th2 balanced state to boost immunization and the unique preparation of Xinfuning can strengthen such function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Obstetrics and Gynecology
Year:
2009
Type:
Article
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