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Association between survivin promoter -31C/G polymorphism and genetic susceptibility to sporadic colorectal cancer / 中国病理生理杂志
Chinese Journal of Pathophysiology ; (12): 2344-2348, 2009.
Article in Chinese | WPRIM | ID: wpr-404987
ABSTRACT

AIM:

To investigate the association between -31C/G polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in southern Chinese population.

METHODS:

survivin -31C/G genotypes were determined by PCR-RFLP in 711 healthy controls and 702 CRC cases.

RESULTS:

The number of CRC patients carrying with CC genotype was much higher than that of controls (36.5 % vs 26.2%,χ~2 =17.89,P<0.01). Compared to CC genotypes, CG, GG genotypes and G allele carriers had a significantly decreased risk of CRC, with the decrease being 0.61-fold (95% confidence interval=0.46-0.80, P<0.01), 0.52-fold (95% confidence interval=0.38-0.71,P<0.01) and 0.58-fold (95% confidence interval=0.45-0.74, P<0.01), respectively.

CONCLUSION:

survivin gene -31C/G polymorphism is associated with sporadic CRC risk, the G variant genotype is the independent protective factors against sporadic CRC in southern Chinese population.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pathophysiology Year: 2009 Type: Article