Effects of carvedilol on murine viral myocarditis / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 2319-2322, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-404992
ABSTRACT
AIM:
To observe the effects of carvedilol on murine viral myocarditis model.METHODS:
A total of 188 inbred male BALB/c mice of 4-6 weeks were divided into 4 groups myocarditis group (group C, n=60), metoprolol treatment group (group M, n=60), carvedilol treatment group (group K, n=60), control group (group B, n=8). Myocardial histopathololgic changes were observed. The concentrations of cardiac troponin I (cTn-I) were detected by chemiluminescence immunoassay (CLIA). Western blotting was performed to analyze the contents of phosphorylated p38MAPK in myocardium.RESULTS:
Metropolol and carvedilol lightened myocardial histopathololgic changes at acute stage, decreased cTn-I concentrations and myocardial phosphorylated p38MAPK value compared with myocarditis group. Treatment with carvedilol was more effective than treated with metropolol on those indexes.CONCLUSION:
Carvedilol protects against viral myocarditis by inhibition of p38MAPK signal transduction pathway through blockade of β_1 and β_2 adrenergic receptors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2009
Type:
Article
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