Optimization of riboflavin sodium phosphate loading to calcium alginate floating microspheres by response surface methodology / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6): 682-686, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-405099
ABSTRACT
Objective:
To investigate the preparation, optimization and in vitro properties of riboflavin sodium phosphate floating microspheres.Methods:
The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method.Results:
The properties of the microspheres were investigated, including the buoyancy, release, appearance and entrapment efficiency. The formulation was optimized by response surface methodology (RSM).Conclusion:
The optimized microspheres were round. The entrapment efficiency was 57.49%. All the microspheres could float on the artificial gastric juice over 8 hours. The release of the drug from the microspheres complied with Fick' s diffusion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Peking University(Health Sciences)
Year:
2009
Type:
Article
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