Your browser doesn't support javascript.
loading
The change of interleukin-5 in peripheral blood from asthma patients during paracmasis and intervention of taurine / 国际检验医学杂志
International Journal of Laboratory Medicine ; (12): 942-944, 2009.
Article in Chinese | WPRIM | ID: wpr-405722
ABSTRACT
Objective To investigate the change of interleukin-5(IL-5)level and mRNA expression in peripheral blood from asthma patients during paracmasis before and after administration of taurine,and explore its clinical significance.Methods A randomized,placebo control,double blind and prospective study was conduced in 84 patients with mild to moderate asthma During paracmasis.The patients were randomly divided into group A(taurine taken orally for one year from beginning of paracmasis)and group B(placebo taken orally for one year from beginning of paracmasis).The symptom score of asthma,lung function paramcter(FEVI),IL-5 level and mRNA expression in peripheral blood were measured and rccorded before and after treatment.The results were compared with those of healthy control group(group C,n=10).Results There were significant differences in the above indices between group A and group Bsymptom score of asthma(12.5 + 4.8 vs 15.2±5.1);lung function parameter[FEV1(L)2.6±0.5 vs 2.2±0.8];IL-5 level(pg/mL)(16.3±4.5 vs 26.9 ±12.7);IL-5 mRNA(0.21 ± 0.09 vs 0.35 ± 0.14).The basic level and mRNA expression of IL-5 were significantly higher in group A and group B than that in group C.The serum level and mRNA expression of IL-5 were positively correlative with symptom score of asthma in group A(r=0.42,P<0.05).Conclusion The exists ovcrexpression of IL-5 in asthma patients during paracmasis and IL-5 level reflects the scverity of pathogenetic condition.Therefore,IL-5 measurement may provide a good reference for clinical therapy of asthma.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Observational study Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2009 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Observational study Language: Chinese Journal: International Journal of Laboratory Medicine Year: 2009 Type: Article