Effect of αⅡb Ala477Pro(A446P) mutation of the platelet glycoprotein on the expression of αⅡbβ3 complex

Xiaoyu YUAN; Fangping CHEN; Kun XIA; Gan FU; Zaifu JIAN; Qinzhi JIE; Guangping WANG

Effect of αⅡb Ala477Pro(A446P) mutation of the platelet glycoprotein on the expression of αⅡbβ3 complex / 中南大学学报(医学版)

Xiaoyu YUAN; Fangping CHEN; Kun XIA; Gan FU; Zaifu JIAN; Qinzhi JIE; Guangping WANG.

Journal of Central South University(Medical Sciences) ; (12): 712-717, 2009.

Article in Chinese | WPRIM | ID: wpr-405821

ABSTRACT

ABSTRACT

ly reduces the expression of αⅡbβ3 complex on the membrane. This mutation may interfere the formation of αⅡbβ3 complex or impair the proper conformation of αⅡb subunit.

Glanzmann thrombasthenia; integrin αⅡbβ3; β-propeller; mutation; expression

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2009 Type: Article