Role of activating transcription factor 2 in the growth of mandible condyle chondrocytes / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 459-462, 2009.
Article
in Zh
| WPRIM
| ID: wpr-405934
Responsible library:
WPRO
ABSTRACT
Objective: To study the role of activating transcription factor 2 (ATF-2) in the growth of mandibular condyle cartilage. Methods: Primary chondrocytes of condyle were cultured. Expression plasmid of ATF-2 and plasmid bcl-2 promoter were transfected into chondrocytes. Luciferase assay and Western blot were used. Results: The absence of ATF-2 in mandibular condyle chondrocytes resulted in a decline in bcl-2 promoter activity, reduction in bcl-2 protein level. Conclusion: The results strongly imply that ATF-2 is required for adequate bcl-2 expression, and play a significant role in controlling growth plate chondrocyte progression.
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2009
Type:
Article