Different gene expressions in human periodontal cells after being treated with Emdogain / 实用口腔医学杂志
Journal of Practical Stomatology
; (6): 556-559, 2009.
Article
in Zh
| WPRIM
| ID: wpr-406070
Responsible library:
WPRO
ABSTRACT
Objective:To study the different gene expressions in human periodontal cells after being treated with Emdogain(EMD). Methods: The fourth passage periodontal cells were cultured. Cells in experimental group were cultured with 100 μg/ml EMD in non-serum DMEM for 3 days. Cells in control group were cultured in non-serum DMEM for 3 days. The gene expressions in human periodontal cells were screened with gene chip technique. Results: There were 112 differently expressed genes, 11 down-regulated genes and 101 up-regulated genes. Conclusion: After treated with Emdogain, expression of genes related to cell growth, cell proliferation, biosynthesis of extracellular matrix, angiogenesis and osteogenesis is up-regulated dramatically. Genes related to lipid metabolization and keratinocyte growth is down-regulated in human periodontal cells.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Practical Stomatology
Year:
2009
Type:
Article