Clinical analysis on predisposing factors and fungal characteristics of nosocomial fungal infection in patients with chronic kidney disease / 国际检验医学杂志

ABSTRACT

Objective To investigate the predisposing factors and fungal characteristics of nosocomial fungal infection (NFI) in patients with chronic kidney disease (CKD). Methods The fungal characteristics and laboratory indices were analyzed in patients with and without NFI secondary to CKD. Results The most common infection site of NFI in 65 cases patients with CKD was urinary tract (25 man-times, 38.46%), and the second common site was digestive tract (20 man-times, 30.77%). The most common pathogenic fungus was Candida albicans (68.49%), followed by Candida tropicalis (17.81%). The sensitivity of Candida albicans to fluconazol was 90%. The predisposing factors included prolonged length of stay, anaemia, malnutrition, hypogammaglobulinemia, mass proteinuria, renal insufficiency, and the use of large dose of broad spectrum antibiotics, prednisone and cytoxan. Conclusion CKD may predispose to NFI, and the most common fungus is Candida albicans,so the predisposing factors should be controlled so as to prevent NFI among patients with CKD.