Effect of different time aerobic exercises on osseous composition in aging rats / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 5499-5504, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-406224
ABSTRACT
BACKGROUND:
Studies show that proper exercise has the effect of anti-aging, increasing bone mass accumulation and reducing bone mass loss.OBJECTIVE:
To investigate the effect of aerobic exercises on osseous composition In aging rats. DESIGN, TIME ANDSETTING:
A randomized control animal experiment was completed in the Animal Experiment Laboratory of Xi'an Sports Institute from April to June in 2007. MATERIALS A total of 64 clean male SD rats weaned for 2 months were randomly divided into a normal control group, a non-modeling exercise group, an aging model group and a modeling exercise group, with 16 ones in each group. Every 8 rats of each group were sacrificed at the 6th and 9th week respectively.exercise for 6 and 9 weeks. MAIN OUTCOMEMEASURES:
At the end of week 6 and 9, rats in each group were detected regarding to the followingmeasures:
serum alkaline phosphatase, bone gla protein, serum propeptide of type] procollagen, serum total calcium, serum inorganic phosphorus, serum magnesium, urinary calcium, urinary inorganic phosphorus, urinary magnesium, urinary hydroxylysine glycoside. Bone trabecula changes in femoral bone tissue were observed with light microscope.RESULTS:
Compared with the normal control group, the aging model group got a decrease at the following indexes at both week 6 and week 9, namely, serum alkaline phosphatase, serum propeptide of type Ⅰ procellagen, serum total calcium, serum magnesium, urinary calcium, urinary inorganic phosphorus, urinary hydroxyproline. While in the non-modeling exercise group and the modeling exercise group, these above-mentioned indexes increased. Compared with the normal control group, the aging model group got an increase at the following indexes at both week 6 and week 9, namely, serum osteocalcin, inorganic phosphorus, adnary magnesium, urinary hydroxylysine glycoside. While in the non-modeling exercise group and the modeling exercise group, these above-mentioned indexes decreased. In Addition, exercise of 9 weeks led to a better recovery result than that of 6 weeks. The detection under light microscope showed an obvious few bone trabeculas in the aging model group and an increase of bone trabeculas per unit volume in the non-modeling exercise group and the modeling exercise group.CONCLUSION:
Aerobic exercise has a great effect on the morphosis of femoral bone osseous composition in aging rats, and it can delay osteoporosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2009
Type:
Article
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