Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome
Journal of the Korean Pediatric Society
;
: 576-579, 1999.
Article
in Korean
| WPRIM
| ID: wpr-40638
ABSTRACT
Levamisole has been used for nephrotic syndrome due to its immunostimulating, immunomodulating, and steroid-sparing effects. Agranulocytosis, a serious side effect of levamisole, was rare and mostly associated with autoimmune disease, neoplastic disease and HLA B27 except one case in a nephrotic syndrome who was treated with high-dose(5mg/kg QOD) levamisole. This 15 year-old girl with steroid dependent nephrotic syndrome, who was negative for HLA B27, was treated with the usual recommended dose of levamisole(2.5mg/kg QOD). She developed agranulocytosis after 5 weeks of therapy and completely recovered in 11 days after discontinuation of levamisole.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Levamisole
/
Agranulocytosis
/
Nephrotic Syndrome
Limits:
Adolescent
/
Child
/
Female
/
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1999
Type:
Article
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