The examination and the expression of urotensin Ⅱ and their relationship with pre-eclampsia / 国际检验医学杂志

ABSTRACT

Objective To explore the effect of urotensin Ⅱ (U Ⅱ) in occurrence and development of pre-eclampsia through the examination of U Ⅱ in pre-eclampsia pregnant woman and newborn cord blood and the expression of U Ⅱ mRNA in placenta. Methods 1) The serum U Ⅱ of peripheral blood and newborn cord blood was determined in 40 pre-eclampsia patients and 20 normal pregnant women (control group) by using ELISA method. 2) The U Ⅱ mRNA expression level in placenta tissue was simultaneously examined with RT-PCR method. Results The concentration o{ serum U Ⅱ in pre-eclampia patients was obviously higher than that in control group (P<0.05).2) The U Ⅱ mRNA ex-pression level in placenta tissue in pre-eclampsia patients was obviously higher than that in control group (P<0.05). Conclusion U Ⅱ plays an important role in development of ischemia, anoxemia and atherosclerosis of placenta tissue.