Clinical analysis of coagulation factors and inflammatory reaction in coronary heart disease / 国际检验医学杂志

ABSTRACT

Objective To understand the relationship between coagulation factors,inflammatory reaction and coronary heart disease(CHD) by analyzing the changes of fibrinogen (Fib), D-dimer (DD) ,C-reactive protein(CRP) and white blood cell (WBC) count. Methods The levels of Fib, DD, CRP and WBC were measured and compared in 91eases with CHD[ineluding 34 cases of acute myocar-dial infarction (AMI group),30 eases of unstable angina peetoris (UAP group) and 27 eases of stable angina peetoris (SAP group)] and 30 healthy controls (healthy control group). Results Plasma con-centrations of Fib, DD, CRP and WBC were the highest in AMI group, followed by those in UAP group,SAP group and healthy control group. There were statistical differences in the above parameters between AMI group and UAP group; so were between UAP group and SAP group. There was no sig-nificant difference between UAP group and healthy control group (P>0. 05). Conclusion The coagu-lation factors and inflammatory reaction are closely associated with occurrence and development of cor-onary heart disease. Four parameters (Fib,DD,CRP and WBC) can be used as adjuvant indicators of differentiating types of CHD and evaluating severity of disease.