HCMV Infection Depress NGF Expression in Human Glioma Cells / 中国病毒学·英文版
Virologica Sinica
;
(6): 209-214, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-406600
ABSTRACT
Human cytomegalovirus (HCMV) is the most common cause of congenital infection, resulting in birth defects such as microcephaly. In this study, RT-PCR and Western Blotting were performed to quantify the regulation of endogenic nerve growth factor expression in neuroglia cells by HCMV infection. The results showed that basal, endogenous NGF expression in U251 was unchanged during early HCMV infection. NGF expression is strongly down-regulated during the latent phase of infection. These results suggest that HCMV can depress the NGF expression in U251 cells.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Virologica Sinica
Year:
2009
Type:
Article
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