Clinical analysis of pathogenic bacteria and drug resistance in bone and joint pyogenic infection / 国际检验医学杂志

ABSTRACT

Objective To evaluate the pathogenic bacteria and drug resistance variation of bone and joint pyogenic infection, and to provide reference for clinical antibiotic therapy. Methods A total of 172 cases with bone and joint pyogenic infection from Jan 2005 to Oct 2007 in the Department of Or- thopedics were retrospectively analyzed with the results of bacterial cultures and antibiocties sensitivity tests of blood, purulence or hydrothorax samples. Results The detection rate of Staphylococcus epi- dermidis, Staphylococcus aureus, Escherhia coil, Acinetobacter baumannii and Enterococcus faecalis accounted for 24.4%, 19.3%, 18. 5 %, 8. 1% and 7.4% respecterly. Conclusion Staphylococci are the major pathogenic bacteria leading to bone and joint pyogenic infection, followed by Escherhia coil, Pseudomonas aeruginosa and fungi. It is suggested that sensitive antibiotics be selected according to drug susceptibility test results. To staphylococcal infection cases, combined application,of antibiotics may improve the therapeutic effect, prevent occurrence of drug resistance, and reduce drug adverse re- action. Early and standard antibiotic therapy and timely local drainage of infection focus contribute to reduce antibiotic resistance and incidence of chronic diseases.