Prescription of naproxen sustained release tablets influences their dissolution in vitro

Weiyan LIANG

ABSTRACT

BACKGROUND:

The pattern of sustained release tablets can reduce medication frequency and prolong release time, which are both beneficial for a better therapeutic effect.

OBJECTIVE:

To prepare naproxen sustained release tablets and investigate the influence of their prescription on the dissolution in vitro.DESIGN, TIME AND

SETTING:

A repeated measurement was carried out in the laboratory of Shunde Polytechnic in September 2005.MATERIALS Naproxen, acrylic resin Ⅱ, hydroxypropyl methyl cellulose(HPMC)and octadecanoic acid were all offered by Guangzhou Xingang Chemical Industry Co., Ltd. Alcohol was analytical pure.

METHODS:

With the orthogonal design, the prescription of naproxen sustained release tablets was screened out by simple factor analysis, consisting of 250g naproxen, 12.5g HPMC (K4M), alcohol, and 1.2g magnesium separate. Drug tab letting was performed with different materials (octadecanoic acid, HPMC, 20% acrylic resin II and polyvidone K30), different viscosities of HPMC (K4M, K15M and K100M), and different rigidities of HPMC (2, 4 and 6kg)at the same granularity and same pressure.MAIN OUTCOME

MEASURES:

The influences of different materials, different viscosities of HPMC and different rigidities of HPMC on the release were observed. The release rate and release effect of naproxen sustained release tablets were determined.

RESULTS:

In accordance with the standard of sustained release tablets, the release for 8 hours of the materials prepared with HPMC at K4M viscosity were satisfied. At the rigidity of 2, 4 and 6 kg, the higher pressure indicated the slower release. The naproxen sustained release tablets sh6wed a good zero order release within 12 hours after the preparation.

CONCLUSION:

The prepared naproxen sustained release tablets have achieved the satisfactory release outcome.