The Effects of N-Methyl_D-Aspartic Acid, and Antagonism by Kynurenic Acid on Neurons in the Cathish Retina
Journal of the Korean Ophthalmological Society
;
: 2303-2312, 1998.
Article
in Korean
| WPRIM
| ID: wpr-40711
ABSTRACT
To investigate the mechanism of the excitatory signal transmission, the effects of N-methyl-D-aspartate(NMDA, ionotropic glutamate agonist) and kynurenic acid(glutamate antagonist) on catfish retinal neurons were explored using conventional intracellular recording techniques. Horizontal cells were depolarized by glutamate, kainate, quisqualate, and NMDA but gyperpolarized by kynurenate. Transient components of both ON-and OFF-bipolar cells were reduced either by glutamate or by NMDA. Kynurenate suppressed sustained components of the third-order neurons or OFF-bipolar cells. Furthermore, kynurenate blocked the depolarizing actions of NMDA on horizontal cells and ON-sustained cells with large ON-transient components. The results suggest that NMDA would exert a tonic depolarization in the horizontal cells and the 3rd-order neurons, and there might be a preferential suppression on the a NMDA receptors by kynurenic acid in the catfish retina.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retina
/
Catfishes
/
N-Methylaspartate
/
Quisqualic Acid
/
Receptors, N-Methyl-D-Aspartate
/
Glutamic Acid
/
Retinal Neurons
/
Kainic Acid
/
Kynurenic Acid
/
Neurons
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
1998
Type:
Article
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