The Expression of Adhesion Molecules in Experimental Allergic and Chemical Conjunctivitis
Journal of the Korean Ophthalmological Society
;
: 2254-2264, 1998.
Article
in Korean
| WPRIM
| ID: wpr-40718
ABSTRACT
The purpose of this study was to assess the expression of ICAM-1, VCAM-1 and PECAM-1 in allergic and chemical conjunctivitis. The allergic and chemical conjunctivitis were induced in C57BL/6 mouse by compound 48/80(C48/80) and 2% characterized clinically by blepharospasm 100%, chemosis 80%, injection AgNO3, respectively. The allergic conjunctivitis was characterized clinically by blepharospasm 100%, chemosis 80%, injection, 40%, mucous discharge 20%, but the chemical conjunctivitis by blepharospasm 80%, chemosis 60%, infection 40% and no mucous discharge at 30 minute after topical application. On the endothelial cells, ICAM-1 was expressed from 1 to 48 hours, VCAM-1 from 6 to 72 hours and PECAM-1 from 1 to 72 hours in allergic conjunctivitis. In chemical conjuctivitis, the expression of ICAM-1 was observed from 6 to 72 hours. The expression of VCAM-1 was observed from 24 and 72 hours. The expression of PECAM-1 was demonstrated from 6 to 72 hours. The expression of cell adhesion molecules, particulary VCAM-1 and PECAM-1, was slighter in chemical conjunctivitis compared to allergic conjunctivitis. In conclusion, experimental allergic and chemical conjunctivitis demonstrate that cell adhesion molecules play a role in part in ocular inflammation and that there are differences between the adhesion molecule expression of two types of confunctivitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blepharospasm
/
Conjunctivitis, Allergic
/
Cell Adhesion Molecules
/
Intercellular Adhesion Molecule-1
/
Conjunctivitis
/
Vascular Cell Adhesion Molecule-1
/
Platelet Endothelial Cell Adhesion Molecule-1
/
Endothelial Cells
/
Inflammation
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
1998
Type:
Article
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