Biological effects of metal ions released from dental alloy / 中国组织工程研究

ABSTRACT

BACKGROUND: Metal ions released from the corrosion process of metal materials used in prosthodontics are directly related to the material biocompatibility, and decide the clinical application value and prospect in the clinical practice.OBJECTIVE: To review the metal ions released from the prosthodontic materials in the oral cavity and their biological effects.RETRIEVAL STRATEGY Using the terms" biocompatibility, dental alloys", we retrieved PubMed data to identify studies published between January 1997 and October 2006 in the English language. A total of 67 manuscripts were researched. Inclusive criteria mental materials used in prosthodontics. Exclusive criteria reparative studies.LITERATURE EVALUATION The included 67 manuscripts were all from PubMed database. After screening, 23 manuscripts were selected, among which, 20 were about original articles, and the maintaining 3 were review.DATA SYNTHESIS: At present, the research of the biological effects of metal ions released from prosthodontic materials focused on the following three areas① The corrosion process of prosthodontic metal and the release of metal ions in the oral cavity Two or even more kinds of metal restorations coexist in one man's oral cavity. Different metal components posed by the potential difference between the original battery will strengthen electrochemical corrosion role. This effect will accelerate the corrosion process and metal ion release, and may have a negative impact on the biocompatibility of prosthodontic materials, but the mechanism of this influence remains unclear. ②The local toxicity of the mental ions released from prosthodontic metal materials used commonly These ions more or less have the risk of potential toxicity, but at the molecular biological level the mechanism of the adverse reaction in oral tissues acquires to be further explored. ③The hypersensitivity reaction induced by the metal ions released from prosthodontic metal materials The ions could have an impact on the expression level of Th1 cytokines during the process of delayed-type hypersensitivity. The future research will focus on the mechanism and the establishment of immunohistochemical detection standards of biocompatibility of these prosthodontic metal materials.CONCLUSION: The metal ions released from prosthodontic materials used commonly have certain cytotoxicity, which can inhibit cell proliferation and cause mucosal diseases, oral contact gingivitis and delayed-type hypersensitivity, but at the molecular biological level the mechanism of these adverse reactions acquires to be further explored.