A Study on Liver Function Indices in Male Lead Workers / 대한산업의학회지
Korean Journal of Occupational and Environmental Medicine
;
: 270-279, 2002.
Article
in Korean
| WPRIM
| ID: wpr-40762
ABSTRACT
OBJECTIVES:
To evaluate the effects of lead on the liver function indices in male lead workers.METHODS:
The study comprised of 274 lead workers and 113 non-lead workers who were confirmed not to have HBsAg (Hepatitis B surface Antigen). Blood lead (PbB), blood zinc protoporphyrin (ZPP) and urinary delta-aminolevulinic acid (ALAU) were selected as parameters for monitoring exposure to lead while aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT) and gamma-glutamyltransferase (gamma-GTP) were chosen as parameters for monitoring liver function. Demographic information, such as age, smoking and drinking histories were collected. The duration of work for the lead workers, and their BMI(body mass index), were also obtained.RESULTS:
After adjusting for possible confounders {age, BMI, work duration, smoking (pack-year) and drinking (bottles of Soju consumed per week)}, blood lead was observed to be a significant variable from the logistic regression analysis of the abnormalities of SGOT( >35 IU/L), with an odds ratio of 1.04 (95 % CI, 1.008-1.066). The amount of alcohol drunk (odds ratio 1.28 95 % CI, 1.054-1.549) and BMI (odds ratio 1.24 95 % CI, 1.075-1.421) were also significant variables. From the multiple linear regression analyses, blood lead was significantly, and positively, associated with SGOT (p<0.05).CONCLUSIONS:
These findings suggest that exposure to lead may have an effect on SGOT in male lead workers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspartate Aminotransferases
/
Smoke
/
Zinc
/
Smoking
/
Linear Models
/
Logistic Models
/
Odds Ratio
/
Alanine Transaminase
/
Drinking
/
Gamma-Glutamyltransferase
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Occupational and Environmental Medicine
Year:
2002
Type:
Article
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