Your browser doesn't support javascript.
loading
Effects of valsartan and indapamide on plasma cytokines in essential hypertension / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 629-634, 2006.
Article in Chinese | WPRIM | ID: wpr-407766
ABSTRACT
Objective To investigate and compare the effect of valsartan and indapamide on inflammatory cytokines in hypertension. Methods Forty-one untreated patients with mild to moderate hypertension and 20 age- and sex-matched normotensives were enrolled in this study. Hypertensives were treated with indapamide 1.5 mg/d (n=20) or valsartan 80 mg/d (n=21) for 4 weeks, and blood samples for determining monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 (MIP-1α), sP-selectin, asymmetric dimethylarginin (ADMA), angiotensin Ⅱ (AngⅡ), and 6-keto-PGF1α were collected before the treatment and 4 weeks after the treatment. Results Hypertensives exhibited significantly higher blood pressure, as well as elevated plasma levels of MCP-1, MIP-1α, sP-selectin and serum level of ADMA compared with the normotensives. Nevertheless, there was no significant difference in serum 6-keto-PGF1α and AngⅡ between the hypertensives and the normotensives. After the treatment with indapamide or valsartan for 4 weeks, both the systolic and diastolic blood pressures, though still higher than those of the normotensives, decreased markedly. After the treatment with indapamide for 4 weeks, MCP-1, MIP-1α and sP-selectin slightly decreased, but not statistically significant (P>0.05). Those cytokines decreased significantly after being treated with valsartan for 4 weeks [(19.16±3.11) pg/mL vs (16.08±2.67) pg/mL, P<0.05; (27.74±8.36) pg/mL vs (17.64±7.59) pg/mL, P<0.05; (2.67±3.18) pg/mL vs (6.15±2.94) pg/mL, P<0.01]. In the 2 treatment groups, 6-keto-PGF1α markedly increased [(61.96±20.81) pg/mL vs (96.72±25.89) pg/mL, P<0.05; (63.25±16.92) pg/mL vs (143.22±43.45) pg/mL, P<0.01]; ADMA decreased significantly [(1.35±0.74) pg/mL vs (0.98±0.56) μmol/L, P<0.05; (1.31±0.68) pg/mL vs (0.71±0.52) μmol/L, P<0.01]. Though AngⅡ slightly increased, no statistical significance was found (P>0.05). Conclusion The levels of MCP-1, MIP-1α, sP-selectin and ADMA were elevated in mild to moderate hypertensives. Valsartan and indapamide have similar blood pressure lowering effect. Valasartan exerts more significant effect on cytokines than indapamide does.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2006 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2006 Type: Article