Analysis of T Cell Clonality in Patients with Systemic Lupus Erythematosus / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12): 15-17, 2001.
Article
in Zh
| WPRIM
| ID: wpr-408086
Responsible library:
WPRO
ABSTRACT
Objective To investigate the T cell clonality in patients with systemic lupus erythematosus (SLE) . Methods T cell clonality in peripheral blood lymphocytes from six patients with active SLE was analyzed using reverse transcriptase- polymerase chain reaction (RT- PCR) and GeneScan technique. Results T cell receptor (TCR) Vβ PCR products from two patients were derived from polyclonal T cells, however, TCR Vβ9, Vβ2, VβI, Vβ2 pioducts from the other four patients were derived from oligoclonal T cells respectively.ConclusionT cells from patients with SLE demonstrated a striking oligoclnality and their clonal expansion may be a specific response driven by autoantigens.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Dermatology
Year:
2001
Type:
Article