Inhibition of matrine on potassium currents in guinea pig ventricular myocytes / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 167-173, 2007.
Article
in Zh
| WPRIM
| ID: wpr-408093
Responsible library:
WPRO
ABSTRACT
AIM To elucidate the possible antiarrhythmic mechanism of matrine. METHODS Whole-cell patch-clamp technique was used to record ionic currents in ventricular myocytes. RESULTS In guinea pig ventricular myocytes, matrine 100 μmol·L-1 prolonged 90% action potential duration (APD90) by 40% at a stimulation of 0.1 Hz in a frequency-independent manner, inhibited IK1 by 47% at the test potential of -120 mV, reduced IKr,tail by 50% and had no effect on IKs,tail. CONCLUSION Matrine prolonged APD through blockade of multiple potassium currents, which may relate to its antiarrhythmic efficacy.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Pharmacology and Toxicology
Year:
2007
Type:
Article