Clinical effect in treatment of Alzheimer disease based on the conditions of heart and kidney / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 162-164, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-408456
ABSTRACT
BACKGROUND:
Clinically Alzheimer disease (AD) is characterized by obscurity in onset, decline of intelligence, and dysfunctions of behavior and nerve system. The essence of AD is impairment of memory and cognition.OBJECTIVE:
To explore the effective mechanism of tiaoxin recipe (TXR)and bushen recipe (BSR) in treating AD.DESIGN:
Randomized controlled study.SETTING:
Shanghai Institute of Traditional Chinese Medicine for Geriatrics.PARTICIPANTS:
Totally 60 AD patients were selected from Shanghai Institute of Traditional Chinese Medicine for Geriatrics from October 1999to January 2000.METHODS:
Sixty patients with AD were divided into 3 groups, with 20in each group. The patients in TXR and BSR group took respectively TXR and BSR 10 mL once, 2 times per day. The patients in donepezil (Dp)group took a Dp capsule once a day, h.s (Dp was produced in England Boots Company, 5 mg per capsule). For a course consisted of 12 weeks.The changes of Mini mental state examination (MMSE) score, Activity of Daily Living Scale (ADL) score, neuropsychological testing (NPT) score,including FULD object-memory evaluation (FOM), rapid verbal retrieval (RVR), digit span test (DS) and block design (BD), as well as the overall operational evaluation before and after treatment were analyzed.MAIN OUTCOMEMEASURES:
Scores of MMSE, ADL, NPT and the overall operational evaluation.RESULTS:
Totally 60 patients entered the final analysis. ① MMSE scores in the 3 groups were decreased after treatment as compared with those before treatment (P < 0.01). Total effective rates were 70%, 65% and 75% respectively (P > 0.05). ② ADL scores in the 3 groups were decreased after treatment as compared with those before treatment (P < 0.05or P < 0.01). Total effective rates were 45%, 45% and 40% respectively (P > 0.05). ③ Total effective rates were 70%, 65% and 75% respectively (P > 0.05). ④ Scores of FOM were increased in the TXR and the Dp group after treatment as compared with those before treatment (P < 0.05). RVR scores in the three groups were increased after treatment as compared with tbose before treatment (P < 0.05); DS scores were increased in TXR group and Dp group after treatment as compared with those before treatment (P < 0.05 or P < 0.01); and BD scores in BSR group were increased after treatment as compared with those before treatment (P < 0.05).CONCLUTION TXR, BSR and Dp can improve cognitive function and daily living ability of AD patients, and TXR and BSR are effective TCM drugs in treating AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2006
Type:
Article
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