Pharmacokinetics and bioequivalence of piracetam tablets in healthy volunteers / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 1144-1147, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-408574
ABSTRACT
AIM:
To study the bioequivalence of piracetam tablets in Chinese healthy volunteers. METH-ODS Twenty volunteers were randomly divided into two groups (test and reference), with double cross-over design and single-dose oral administration. The concentration of piracetam in serum was determined by HPLC. The main pharmacokinetic parameters were calculated and the bioequivalence was evaluated with DAS2.0 practical pharmacokinetics program.RESULTS:
The pharmacokinetic parameters of piracetam tablets were as follows t1/2 were 5.50±1.48 and 4.29±1.00 h, Cmax were 21.47± 6.27 and 20.96±5.10 mg·L-1, Tmax were 0.70±0.46 and 0.66± 0.36 h, AUC0-24h were 93.44± 16.61 and 96.67± 18.50 mg·h·L- 1. The relative bioavailability of the test preparation was 99.8%± 22.7%. CONCLU-SION The test and reference preparations were bioequivalent and may be prescribed interchangeably.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2006
Type:
Article
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