A simple and repeatable orthotopic model of the A549 cell line in nude mice / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 1102-1105, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-408576
ABSTRACT
AIM:
To establish a simple and repeatable orthotopic animal model of the A549 cell line.METHODS:
A549 cells in matrigel were inoculated into left lung or right flank of nude mouse. The growth pattern of A549 tumors and the chemotherapeutic efficacy of carboplatinum were studied.RESULTS:
Tumors generated and dispersed widespreadly to contralateral lung. Tumors in lung were less susceptible to carboplatinum than those growing in flank.CONCLUSION:
A simple and repeatable orthotopic animal model of the A549 cell line was presented, this allows researchers to evaluate novel compounds and new drugs for treatment of human lung cancer.KEY WORDS A549 cell line; orthotopic model; nude mice
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2006
Type:
Article
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