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Effect of soybean isoflavones on ventricular remodeling induced by myocardial infarction in rats / 中国新药与临床杂志
Chinese Journal of New Drugs and Clinical Remedies ; (12): 241-247, 2006.
Article in Chinese | WPRIM | ID: wpr-408759
ABSTRACT

AIM:

To investigate the effect of soybean isoflavones (SI) on ventricular remodeling induced by myocardial infarction (MI).

METHODS:

MI was induced by permanent ligation of the left anterior descending coronary artery (LAD) in male Sprague-Dawley (SD)rats. Rats were randomly divided into six groups shamThree hours after the operation, the drugs or solvent were administrated ig qd for 35 d. Twenty-four hours after the last administration, heart rate (HR), left ventricular end-diastolic pressure (LVEDP), peak systolic left ventricular pressure (Peak), maximal rate of left ventricular pressure rising (+dp/dtmax), maximal rate of left ventricular pressure declining (-dp/dtmax) and myocardial maximal shortening velocity (Vmax) were measured. After above hemodynamic parameters were measured, hearts were extracted. The ratio of total ventricle weight to body weight(TVW/BW) was calculated. Myocardial collagen was shown with the collagen-specific picrosirius red stain,myocardial interstitial collagen volume fraction(ICVF), perivascular collagen volume fraction(PCVF), infarct size,septal thickness (ST) and left ventricular diameter (LVD) were measured by image analysis system.

RESULTS:

(31 ± 5) %, respectively, all of which were significantly smaller than that in MI group (( 38.9 ± 2.9) %, P < 0.01 ).In MI group, TVW/BW, LVD, ICVF and PCVF were remarkably increased compared with those in sham group (P < 0.01 ). The increased TVW/BW, LVD, ICVF and PCVF were significantly reduced by treatment with eaprats in MI group was significantly decreased than that in sham group (P < 0.01 ). The reduced ST could be in-dp/dtmax and Vmax were decreased (P < 0.01 ), while LVEDP was increased (P < 0.01 ), significantly. The reSION SI can improve cardiac function and ventricular remodeling induced by myocardial infarction in the rat.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of New Drugs and Clinical Remedies Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of New Drugs and Clinical Remedies Year: 2006 Type: Article