Function of ginger on cerebrovascular disease and its gateway / 中国组织工程研究

ABSTRACT

OBJECTIVE: A probing study of pharmacological action and gateway of ginger, a traditional Chinese medicine, on cerebrovascular disease.DATA SOURCE Retrieved on documents via computer in Medline from January 1980 to December 2003 about function and mechanism of ginger on cerebrovascular disease with retrieval subjects: "Zingiber officinale Rosc", and the defined type of language in English.STUDY SELECTION Retrieved on documents relative to ginger, and screened the documentations about function and mechanism of cerebrovascular disease one by one, and including in vivo animal test, in vivo and in vitro and clinical researches.DATA EXTRACTION Totally 108 articles about ginger were retrieved,of which 24 articles relative to analysis of chemical compositions were included; 80 articles about pharmacological action were retrieved, including 29 articles about function of cardio-cerebral vessels, 8 articles about function of cerebral vessels. The articles were classified, summarized and appraised respectively, and views and prospects about the existing problems were put forward.DATA SYNTHESIS:①Pharmacological action of ginger with regard to the formation of anticoagulation and antithromboembolism Test in vitro indicated that the water extract and its organic solvent extract could inhibit platelet aggregation and blood platelet thromboebolism, and its function would be enhanced with the enlargement of dosage. Test in vivo indicated that administration by gavage in terms of water extract, volatile oil, and ethyl alcohol could inhibit platelet aggregation. The inhibitory function of ginger on platelet aggregation were related with cyclooxygenase activity. Clinical researches showed that Rhizoma Zingiberis Recents and powder of ginger could inhibit platelet aggregation, but the effect would depend on the dosage of ginger.②Pharmacological action with regard to improvement of ceberal circulation Manifested by remission of vasospasm, diminution of velocity of blood flow, improvement of metabolism of ischemic tissue and the anoxic condition and positive protection for the brain.CONCLUSION: Pharmacological actions of ginger on cerebrovascular disease were manifested with anticoagulation and antithromboembolism and improvement of ceberal circulation.