The Effect of d-Tubocurarine and Lidocaine on Elevated Serum Potassium Level with Succinylcholine / 대한마취과학회지

ABSTRACT

Succinylcholine has been used extensively for endotracheal intubation as a short-acting muscle relaxant. Intravenous administration of succinylcholine may be associated with adverse effects including elevated serum potassium and creatine phosphokinase, postoperative myalgia, changes in cardiac rate and rhythm, elevated intraocular pressure and intragastric pressure. Although elevated serum potassium is usually slight in normal person, it can be greater in disease states such as burn, massive trauma, uremia, neuromuscular disorders, CNS injury and tetanus. In the present study, the influence of d-Tubocurarine and lidocaine on the serum potassium level was observed in 80 patients undergoing elective surgery and without electrolyte. abnormality. The patients were divided into four groups of 20 cases. control group serving as control. dTc group receiving 3 mg of d-Tubocurarine as pretreatment prior to succinylcholine administration lidocaine group receiving 1 mg/kg of lidocaine as pretreatment prior to succinylcholine administration dTc with lidocaine group receiving d-Tubocurarine with lidocaine as pretreatment prior to succinylcholine administration Blood samples for electrolyte measurement were drawn before induction and 3, 5 and 10 minutes after the administration of succinylcholine. The following results were obtained; 1) Serum potassium levels were significantly increased in the control group(p<0.05) and lidocaine group(p<0.001). 2) Serum potassium level were slightly incerased, but not significantly in the dTc group and dTc with lidocaine group. 3) Serum sodium levels were slightly decreased in all groups, but not significantly. 4) Serum chloride levels were slightly increased in all groups, but not significantly.