Role of dopamine- and cyclic adenosine monophosphate-regulated phosphoprotein in neuronal signal transmission and integration / 中国组织工程研究

ABSTRACT

OBJECTIVE: To elucidate the central role of dopamine-and cyclic adenosine 3 ',5 '-monophosphate-regulated phosphoprotein (DARPP 32) in neuronal signal transmission and integration to provide a theoretical basis for study of the clinical treatment and functional rehabilitation of neurological diseases.DATA SOURCES A computer-based search was conducted for related literatures published between January 1980 and December 2004 indexed in Medline Database, using the key words of "DARPP-32" and "role",with the language of the articles limited to English. A similar search was also conducted for Chinese articles indexed in Chinese Academic Journal Full-text Database and Wanfang Database, using the equivalent Chinese terms for the same key words.STUDY SELECTION A preliminary selection of the 98 retrieved articles was carried out to identify randomized controlled experiments or trials and relevant chapters in monographs for inclusion, with repetitive studies and Meta-analysis excluded.DATA EXTRACTION Totally 29 original articles, reviews and monographs pertaining to the study of DARPP-32 were collected. Summarization, synthesis and abstraction of the articles was carried out according to the results and discussions in the articles.DATA SYNTHESIS: DARPP-32 is expressed in the neurons in the neostriatum and other nuclei, performing multiple roles in signal regulation and integration. After binding to corresponding receptors, dopamine, glutamate or other neurotransmitters cause phosphorylation or dephosphorylation of DARPP-32 at 34-Thr or other three sites to affect the activities of such important phospholipases as phospholipase 1 and 2B, so that all the signals from various pathways can be integrated and the neuronal functions and the behaviors governed by these neurons altered. The functions of DARPP32 are related to many neurotransmitters and their receptors and can be explored using gene knockout technique.CONCLUSION: DARPP-32 plays a central role in the complex signal transmission and integration processes of neurons. The research of DARPP32 may provide evidence and effective means for the therapy of neurological diseases such as Parkinson disease, Huntington disease, schizophrenia and drug addiction.