Pathogenesis of diabetes mellitus and its relationship with neuroendocrine immunomodulation network / 中国组织工程研究

ABSTRACT

OBJECTIVE: To review the pathogenesis of diabetes under the guidance of the theories of neuroendocrine immunomodulation(NIM) network combined with the understanding of diabetes in traditional Chinese medicine.DATA SOURCES Computer was used to search for the articles published from January 1980 to January 2005, with key words of "diabetes mellitus,pathogenesis, neuroendocrine immunomodulation, and traditional Chinese medicine " and the language of the papers was limited to "English". Also,computer and manual search for the articles in NLW and CNKI data banks from January 1990 to January 2005 were made with the language of the papers being limited to "Chinese" and key words of "diabetes, pathogenesis,neuroendocrine immunomodulation, traditional Chinese medicine" . Manual search was made for book chapters on the treatment of diabetes by traditional Chinese medicine and papers on the relation of diabetes with neuroendocrine immunoregulation network published after 1980.STUDY SELECTION A rough check was made firstly to the materials to choose the articles on diabetes and the relationship with neuroendocrine immunoregulation network. Inclusion criteria ① randomized clinical trial (RCT), single-, double- or non-blinded methods were used; ②non-randomized controlled trial; ③ anterior-posterior controlled trial. Exclusion criteria repeated studies were excluded.DATA EXTRACTION Thirty-three articles on pathogenesis of diabetes were obtained and among them 21 were consistent with the above criteria and 12 were excluded for repetition of the same studies.DATA SYNTHESIS: Twenty-one articles on the relation of the pathogenesis of diabetes with neuroendocrine immunoregulation and with the traditional Chinese medicine were analyzed to investigate the internal relations of the three.CONCLUSION: Diabetes mellitus is induced by the interaction between genetic and environmental factors, and the imbalance among insulin, counterregulatory hormones and other factors such as hypothalamic pituitary-adrenal (HPA) axis, thymus gland in neuroendocrine immunomodulation (NIM) network. The authors propose that the NIM network theory might be as a bridge to link modern medicine and the traditional Chinese medicine that is helpful to understand the pathogenesis of diabetes mellitus.CONCLUSION: Diabetes mellitus is induced by the interaction between genetic and environmental factors, and the imbalance among insulin, counterregulatory hormones and other factors such as hypothalamic pituitary-adrenal (HPA) axis, thymus gland in neuroendocrine immunomodulation (NIM) network. The authors propose that the NIM network theory might be as a bridge to link modern medicine and the traditional Chinese medicine that is helpful to understand the pathogenesis of diabetes mellitus.