Application and mechanism of therapeutic principles in Chinese medicine in ventricular reconstruction after myocardial infarction / 中国组织工程研究

ABSTRACT

OBJECTIVE: Ventricular reconstruction after myocardial infarction is one of the important dangerous factors to the remote occurrence of cardiac functional disturbance. Chinese medicine is of unique advantages in the main therapeutic principles and methods for the post-infarct ventricular reconstruction.DATA SOURCES To search for and proofread the relevant literatures on the researches on post-infarct ventricular reconstruction in Nuclear Journals of Chinese Medicine from January 1987 to December 2003 by www. google. com,Medline. Referring word ventricular reconstruction,myocardial infarction,removing blood stasis and resolving phlegm,clearing heat and nourishing yin.STUDY SELECTION Fifty-six papers on post-infarct ventricular reconstruction were selected, excluded the original literatures on non-random researches and included the original literatures on non-blind researches.DATA EXTRACTION Of 56 papers,14 papers were deleted for they were repeated in the contents in different degrees. The rest 42 papers were classified and 12 papers of which were selected as the references.DATA SYNTHESIS: Myocardial infarction is the syndrome in which the root cause is deficiency and the symptoms are excess. The main therapeutic principles are to benefit qi,eliminate stasis,resolve phlegm,activate blood circulation,regulate qi,strengthen spleen,clear away heat and nourish yin. Of which, benefiting qi is the primary of the treatment for the root cause and nourishing yin is the secondary of the treatment for the root cause. Eliminating stasis and resolving phlegm is the primary of the treatment for symptoms,regulating qi and clearing away heat is the secondary of the treatment for symptoms. To benefit qi and activate blood circulation can improve blood dynamics to probably benefit the protection of ventricular reconstruction by reducing ventricular pressure and vascular resistauce of systematic circulation.CONCLUSION: After myocardial infarction, it happens inadaptable myocardial hypertrophy and external stromal accumulation and fibrosis of cardiac muscles. Long-term application of the principles for eliminating stasis,resolving phlegm,clearing away heat and nourishing yin can resist ventricular reconstruction and improve post-infarct cardiac function.