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Sini tang for quality of life of patients with coronary heart disease / 中国组织工程研究
Chinese Journal of Tissue Engineering Research ; (53): 195-197, 2005.
Article in Chinese | WPRIM | ID: wpr-409591
ABSTRACT

BACKGROUND:

In the evaluation on the effects of intervention on the patients with angina pectoris,whether the quality of life is improved or not is a very important factor while the symptoms and physical signs are benefited.

OBJECTIVE:

To probe into the intervention effects of sini tang,the classic formula,on angina pectoris of coronary heart disease and compare the effects of simple Chinese herbs,western medicine and integrated traditional Chinese and western medicine on quality of life.

DESIGN:

Prospective observation and control study in which the patients with angina pectoris of coronary heart disease were taken as the objects.

SETTING:

Department of Traditional Chinese Medicine of a Hospital Affiliated to a University.PARTICIPANIT The 88 cases in total were the patients with angina pectoris of coronary heart disease in the clinic of Department of Traditional Chinese Medicine of First Hospital Affiliated to Sun Yat-sen University from February to August 2003. Inclusion criteria those compiled with "Guide Principles of Pharmaceutical Clinical Study in Cardiac Vascular System" and "Standards on Differentiation of Coronary Heart Disease with Chinese Medicine". Exclusion criteria those complicated with various severe diseases. All the patients were randomized into sini tang group,isosrbide dinitrate group and allied medication group of 29,30 and 29 cases successively.

METHODS:

In sini tang group,isosrbide dinitrate group and allied medication group,sini tang,isosrbide dinitrate and sini tang allied with isosrbide dinitrate were prescribed successively. At the beginning and the end of treatment, it was to observe the attack frequency,condition, severity and persistent duration of angina pectoris and to record electrocardiogram (ECG).The evaluation on quality of life was carried on before and two weeks after medication with the unified inventory and determination device.MAIN OUTCOME

MEASURES:

Comparisons of therapeutic effect on angina pectoris control,ECG and evaluation on life quality in every group.

RESULTS:

Both isosrbide dinitrate and sini tang relieved remarkably angina pectoris, improved ECG and quality of life in physical symptoms, health pleasure and depression level(P<0.01) . The result of sini tang on improving the quality of life in above-mentioned three aspects was better than that of isosrbide dinitrate(P<0.01) . But the allied medication improved clinical therapeutic effects and quality of life (health pleasure and depression level) best(P<0.01).

CONCLUSION:

Sini tang benefits the improvement of quality of life of patients with angina pectoris. But during clinical medical intervention,the advantages of integrated traditional Chinese and western medicine should be adopted.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Practice guideline Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Practice guideline Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2005 Type: Article