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Interventional effect of fluoxetine on the quality of life in depressive patients with breast cancer / 中国组织工程研究
Chinese Journal of Tissue Engineering Research ; (53): 216-217, 2005.
Article in Chinese | WPRIM | ID: wpr-409812
ABSTRACT

BACKGROUND:

There are many studies on the quality of life (QOL) of patients with breast cancer at home and abroad at present. But the effect of antidepressants on the QOL of depressive patients with breast cancer is not clear yet.

OBJECTIVE:

To investigate the effect of fluoxetine on the QOL of depressive patients with breast cancer.

DESIGN:

A self-controlled and observational comparative study of taking the patient as the subjects.

SETTING:

The research institute of medical psychology and psychiatric specialty in two universities and a psychiatric department in a city hospital.

PARTICIPANTS:

Sixty-three female post-operative patients with breast cancer hospitalized in the First Affiliated Hospital and Second Affiliated Hospital of China Medical University and Dalian Tumor Hospital, with an average age of (50 ± 9) years.

INTERVENTIONS:

Sity-three depressive patients with breast cancer were treated with fluoxetine for 8 weeks. Treatment emergent symptom scale (TESS) and relative laboratory examinations were used to evaluate the safety of fluoxetine to depression and anxiety of depressive patients with breast cancer. QOL of WHO scale was used to assess the QOL of the patients before and after administration.MAIN OUTCOME MEASURS①Score of every index of QOL of WHO;②Side effects and adverse effects.

RESULTS:

The scores of physiology, psychology and independence in QOLafter 8 weeks' administration(16.30 ±2.17, 14.41 ± 1.85, 16. 90 ± 1.53)were significantly higher than those before grouping (13.61 ±2.46,12.98 ± 2.65, 13.65 ± 2.45) ( t = 6.52, P < 0.01; t = 2.41, P< 0.05; t= 8.93, P < 0.01 ). No obvious side effect was observed during administration.

CONCLUSION:

Fluoxetine can significantly improve the QOL of patients with breast cancer and there are fewer side effects during the treatment.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2005 Type: Article