Effects of Huperzine A on the memory and learning behavior in D galactose induced senile mice

Peiyong QIU; Zhengyue CHEN; Yongxue WANG; Jixia ZHANG; Zizhao WU

ABSTRACT

BACKGROUND:

Huperzine A is a reversible choline enzyme(CHE) inhibitor initially developed in China,which has favorable therapeutic effectiveness in benign memory dysfunction,and could significantly promote the learning process and memory reappearance in rodent animals.

OBJECTIVE:

To comprehend the impacts of Huperzine A on the enhancement of learning, memory and behavior in platform and maze experiments in D Galoctose(Gal) induced senile mouse model.

DESIGN:

A randomized and controlled trial.

SETTING:

Institute of Pharmaceuticals of Xinxiang Medical College. MATERIALSStudy was performed in the Laboratory of Physiology and the Institute of Pharmaceuticals of Xinxiang Medical College from January to December in 2002.A total of 100 healthy Kunming mice were selected for platform and electric maze experiments with 50 mice in each experiment.Huperzine A tablet was obtained from Henan Zhulin Zhongsheng Pharmaceutical Company Limited(batch number031001).D Gal is the product of Shanghai No.2 Reagent Factory. MAIN OUTCOME

MEASURES:

The latency in the safe area on the platform and the times of electric shock occurred within 5 minutes were observed in mice in platform experiment;the times of the mice mistakenly escaping to the right electric attacking area were observed in mice in electric maze experiment.

CONCLUSION:

Huperzine A can effectively improve the learning and memory ability of D Gal induced senile mice, and there is dose effect relationship within certain range. Qiu PY,Chen ZY,Wang YX,Zhang JX,Wu ZZ.Effects of Huperzine A on the memory and behavior in D galactose induced senile mice.Zhongguo Linchuang Kangfu 2005;9(4)247- 9(China) [www.zglckf.com]