Molecular Mechanisms of Cell-cell Recognition / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
;
(12): 385-392, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-410073
ABSTRACT
Cell-cell recognition is the key for multicellular organisms to survive. This recognition critically depends on protein-protein interactions from opposing cell surfaces. Recent structural investigations reveal unique features of these cell surface receptors and how they interact. These interactions are specific, but usually relatively weak, with more hydrophilic forces involved in binding. The receptors appear to have specialized ways to present their key interacting elements for ligand-binding from the cell surface. Cell-cell contacts are multivalent. A large group of cell surface molecules are engaged in interactions. Characteristic weak interactions make possible for each individual molecule pair within the group to constantly associate-dissociate-reassociate, such that the cell-cell recognition becomes a dynamic process. The immunological synapse is a good example for immune receptors to be orchestrated in performing immunological function in a collective fashion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Progress in Biochemistry and Biophysics
Year:
2004
Type:
Article
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