Effect of naloxone on levels of endothlin-1 (ET-1) and alcitonin gene-related peptide (CGRP) in the plasma and cerebrospinal fluid(CSF) after acute cervical spinal cord injury / 中国组织工程研究

ABSTRACT

Objective The levels of endothelin-1(ET-1) and calcitonin gene-related peptide(CGRP) in the plasma and cerebrospinal fluid(CSF)after acute cervical spinal cord injury. Method ET-1 and CGRP were determined by RIA in order to observe the effects of naloxone on levels of ET-1 and CGRP and neuronal death of cervical spinal cord. Result Levels of ET-1 in the plasma and cerebrospinal fluid(CSF)after acute cerical spinal cord injury increased significantly; but the levels of CGRP in the plasma and cerebrospinal fluid(CSF) decreased markedly. The levels of ET-1 in the plasma and cerebropinal fluid(CSF)decreased markedly after the threapy of naloxone; but levels of CGRP in the plama and cerebrospinal fluid(CSF)increased sinificantly. Conclusion These deta suggest that the lessening of CGRP and increasing of ET-1 may be some important reson causing death of neuron after acute cervical spinal cord injury, and naloxone can protecet cervical spinal cord neuron by increasing levels of CGRP and decreasing levels of ET-1.