A Comparative Study of Latanoprost and Timolol in Treating Patients With Glaucoma or Ocular Hypertension / 中国药房
China Pharmacy
;
(12): 361-362, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410264
ABSTRACT
OBJECTIVE: To confirm the efficacy and safety of latanoprost in treating glaucoma.METHODS: In a double blind, randomized control clinical trial, we compared the efficacy and adverse drug reactions of once daily topically applied 0.005% latanoprost with those of twice daily 0.5% timolol for 12 weeks in patients with open angle glaucoma or ocular hypertension.RESULTS: The study included 46 patients(22 pts.randomized to latanoprost treatment, 24 pts.to timolol) , 46 patients remained at the end of the study.Comparing with baseline diurnal intraocular pressure(IOP) , the IOP reduction(mean±standard deviation) achieved with latanoprost(7.86±2.39) mmHg, (31.1%, P<0.001),and timolol(6.24±2.58)mmHg (24.9%,P<0.001),the difference between the two groups(1.62mmHg) being significant(P<0.01). Two patients treated with latanoprost had foreign body sensation. No other ocular and systemic adverse reactions related to the two drugs were found. CONCLUSION:
The results of this study demonstrated that 0.005% latanoprost applied once daily is well tolerated and more effective in reducing IOP than 0.5% timolol applied twice daily. Thus, latanoprost has the potential for becoming one of the ideal antiglaucoma drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
China Pharmacy
Year:
2001
Type:
Article
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