The damages of adrenal gland in rabbits with neisseria memingococcal septic shock / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 566-568, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410285
ABSTRACT
AIM:
To investigate the damages of adrenal gland in rabbits infected with neisseria meningococci(MC).METHODS:
18 rabbits were injected with MC (1×1011 organism/kg, iv, model group, n=10) or normal saline (control group, n=8).TNF-α was detected in baseline (before challenged), 60 min and 120 min after injection. 120 min after injection, TNF-α immunochemical localization of adrenal gland was detected with ABC methods by electron microscopy.RESULTS:
In model group, TNF-α positive cells were located in medulla and TNF-α released into simus of medulla. The medulla damages were appeared but gland cells of cortex was normal. No damages were showed in control group. TNF-α value of plasm was elevated at 60 min and 120 min after injection compared with control group.CONCLUSION:
TNF-α was released into medulla and resulted in medulla damages after MC challenging. Adrenal cortex didnt damaged in early phase of MC septic shock.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2001
Type:
Article
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