Nitrasotion of Astemizole Followed by Its Determination Using Single-sweep Oscillopolarography / 分析化学
Chinese Journal of Analytical Chemistry
;
(12): 703-706, 2001.
Article
in Chinese
| WPRIM
| ID: wpr-410311
ABSTRACT
Astemizole is nitrasoted with sodium nitrite in 0.12 mo l/L HAc solution at boiling bath for 25 min. The nitrosation product of astemizo le shows a reduction peak by single-sweep oscillopolarography. The peak potenti al is -0.72V (vs.Ag/AgCl). The first-order derivative peak current is propo rtional to the concentration of astemizole in the range of 4.0×10-7~1.6 ×10-5 mol/L (r=0.9997), with detection limit of 2.0×10-7 mol/L . The proposed method has been applied to the determination of astemizole in pha rmaceutical tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Analytical Chemistry
Year:
2001
Type:
Article
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