The Features of the Magnetic Resonance Imaging(MRI) of Children Leukodystrophies / 实用放射学杂志

ABSTRACT

Objective　To detect the features of MRI of children leukodystriphies and to provide a heplful method for clinical diagnosis.Methods　The MRI examination was performed in 50 children with leukodystrophies and the cerebral lobes and cerebral special structures involved by lesions were analyzed.Results　1.There were dominant signs of involving parietal and occipital lobes in ALD,besides the two lobes,the frontal lobe was also involved easily in MLD.All lobes were involved in CD and PMD,and frontal lobe was involved in AD early.The central white matter was involved mainly in ALD,but the central white matter was involed only in MLD and the periphery white matter was spared.The central and periphery white matter were all involved in CD,PMD and AD.Furthermore,the cerebellar white matter is also easily involved in ALD and CD.2.The splenium of corpus callosum was mainly involved in ALD,and the splenium,body and knee of corpus callosum were all involved in MLD.But in CD,PMD and AD,the corpus callosum was spared.The back of the posterior limb of internal capsule was involved in ALD,but the all posterior limb of internal capsule was involved in MLD,and the all internal capsule was involved in CD and PMD.On external capsule,ALD involves its posterior part,but CD and PMD involve its all section.A prominet feature of ALD was involving the corticospinal tract of stem and other leukodystrophies don′t involve the corticospinal tract of stem beside one case later-onset GLD.In addition,the lateral lemmiscus was involved easily in ALD,and thalamus was also involved in ALD,MLD and PMD.Conclusion　As a noninvasive,safe and sensitive method,MRI can be used to find the leukodystrophies early.There are relatively characteristic features in different leokodystrophies,which is useful to clinical diagnosis.